Spin-trapping evidence that graded myocardial ischemia alters post-ischemic superoxide production.

Abstract

The spin trapping agent 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) was used to investigate oxy-radical production in post-ischemic rat hearts previously exposed to 20, 30, or 40 minutes of global ischemia. A hydroxyl spin adduct (DMPO-OH) was identified in coronary effluent during the initial seconds of reperfusion by Electron Spin Resonance (ESR) Spectroscopy… (More)

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Cite this paper

@article{Kramer1987SpintrappingET, title={Spin-trapping evidence that graded myocardial ischemia alters post-ischemic superoxide production.}, author={Joel H. Kramer and Corina Mar{\'i}a Arroyo and Bernard Dickens and William Bernard Weglicki}, journal={Free radical biology & medicine}, year={1987}, volume={3 2}, pages={153-9} }