Spin trapping and cytoprotective properties of fluorinated amphiphilic carrier conjugates of cyclic versus linear nitrones.

@article{Durand2009SpinTA,
  title={Spin trapping and cytoprotective properties of fluorinated amphiphilic carrier conjugates of cyclic versus linear nitrones.},
  author={Gr{\'e}gory Durand and Robert A. Prosak and Yongbin Han and St{\'e}phanie Ortial and Antal Rockenbauer and Bernard Pucci and Frederick A Villamena},
  journal={Chemical research in toxicology},
  year={2009},
  volume={22 9},
  pages={
          1570-81
        }
}
Nitrones have been employed as spin trapping reagent as well as pharmacological agent against neurodegenerative diseases and ischemia-reperfusion induced injury. The structure-activity relationship was explored for the two types of nitrones, i.e., cyclic (DMPO) and linear (PBN), which are conjugated to a fluorinated amphiphilic carrier (FAC) for their cytoprotective properties against hydrogen peroxide (H(2)O(2)), 3-morpholinosynonimine hydrochloride (SIN-1), and 4-hydroxynonenal (HNE) induced… CONTINUE READING