Spin labeled amino acid nitrosourea derivatives--synthesis and antitumour activity.

@article{Zheleva1995SpinLA,
  title={Spin labeled amino acid nitrosourea derivatives--synthesis and antitumour activity.},
  author={Antoaneta M. Zheleva and Zahari Dimitrov Raikov and Maya V Ilarionova and Dimitar Todorov},
  journal={Die Pharmazie},
  year={1995},
  volume={50 1},
  pages={25-6}
}
The synthesis of three spin labeled derivatives of N-[N'-(chloroethyl)-N'-nitrosocarbamoyl] amino acids is reported. The new nitrosoureas are obtained by condensation of the corresponding N-[N'-(2-chloroethyl)-N'-nitrosocarbamoyl] amino acid with 2,2,6,6-tetramethyl-1-oxyl-4-aminopiperidine using dicyclohexylcarbodiimide. Their chemical structures are confirmed by elemental analysis, IR, MS, and EPR spectroscopy. All newly synthesized compounds showed high antitumour activity against the… CONTINUE READING