Spike-timing-dependent synaptic plasticity depends on dendritic location

  title={Spike-timing-dependent synaptic plasticity depends on dendritic location},
  author={Robert C Froemke and Mu-Ming Poo and Yang Dan},
In the neocortex, each neuron receives thousands of synaptic inputs distributed across an extensive dendritic tree. Although postsynaptic processing of each input is known to depend on its dendritic location, it is unclear whether activity-dependent synaptic modification is also location-dependent. Here we report that both the magnitude and the temporal specificity of spike-timing-dependent synaptic modification vary along the apical dendrite of rat cortical layer 2/3 pyramidal neurons. At the… CONTINUE READING
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