Spike timing-dependent synaptic depression in the in vivo barrel cortex of the rat.

@article{Jacob2007SpikeTS,
  title={Spike timing-dependent synaptic depression in the in vivo barrel cortex of the rat.},
  author={Vincent Jacob and Daniel James Brasier and Irina A. Erchova and Dan Feldman and Daniel Shulz},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2007},
  volume={27 6},
  pages={1271-84}
}
Spike timing-dependent plasticity (STDP) is a computationally powerful form of plasticity in which synapses are strengthened or weakened according to the temporal order and precise millisecond-scale delay between presynaptic and postsynaptic spiking activity. STDP is readily observed in vitro, but evidence for STDP in vivo is scarce. Here, we studied spike timing-dependent synaptic depression in single putative pyramidal neurons of the rat primary somatosensory cortex (S1) in vivo, using two… CONTINUE READING