Spike timing-dependent long-term potentiation in ventral tegmental area dopamine cells requires PKC.

@article{Luu2008SpikeTL,
  title={Spike timing-dependent long-term potentiation in ventral tegmental area dopamine cells requires PKC.},
  author={Percy Luu and Robert C Malenka},
  journal={Journal of neurophysiology},
  year={2008},
  volume={100 1},
  pages={533-8}
}
Long-term potentiation (LTP) of excitatory synapses on ventral tegmental area (VTA) dopamine (DA) cells is thought to play an important role in mediating some of the behavioral effects of drugs of abuse yet little is known about its underlying mechanisms. We find that spike timing-dependent LTP (STD LTP) in VTA DA cells is absent in slices prepared from mice previously administered cocaine, suggesting that cocaine-induced LTP and STD LTP share underlying mechanisms. This form of STD LTP is… CONTINUE READING