Spike-and-Wave Oscillations Based on the Properties of GABAB Receptors

  title={Spike-and-Wave Oscillations Based on the Properties of GABAB Receptors},
  author={Alain Destexhe},
  journal={The Journal of Neuroscience},
  pages={9099 - 9111}
  • A. Destexhe
  • Published 1 November 1998
  • Biology
  • The Journal of Neuroscience
Neocortical and thalamic neurons are involved in the genesis of generalized spike-and-wave (SW) epileptic seizures. The cellular mechanism of SW involves complex interactions between intrinsic neuronal firing properties and multiple types of synaptic receptors, but because of the complexity of these interactions the exact details of this mechanism are unclear. In this paper these types of interactions were investigated by using biophysical models of thalamic and cortical neurons. It is shown… 

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