Spike Train Timing-Dependent Associative Modification of Hippocampal CA3 Recurrent Synapses by Mossy Fibers

@article{Kobayashi2004SpikeTT,
  title={Spike Train Timing-Dependent Associative Modification of Hippocampal CA3 Recurrent Synapses by Mossy Fibers},
  author={Katsunori Kobayashi and Mu-Ming Poo},
  journal={Neuron},
  year={2004},
  volume={41},
  pages={445-454}
}
In the CA3 region of the hippocampus, extensive recurrent associational/commissural (A/C) connections made by pyramidal cells may function as a network for associative memory storage and recall. We here report that long-term potentiation (LTP) at the A/C synapses can be induced by association of brief spike trains in mossy fibers (MFs) from the dentate gyrus and A/C fibers. This LTP not only required substantial overlap between spike trains in MFs and A/C fibers, but also depended on the… CONTINUE READING
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