Spider toxins activate the capsaicin receptor to produce inflammatory pain

@article{Siemens2006SpiderTA,
  title={Spider toxins activate the capsaicin receptor to produce inflammatory pain},
  author={J. Siemens and Sharleen Zhou and R. Piskorowski and T. Nikai and E. Lumpkin and A. Basbaum and David King and D. Julius},
  journal={Nature},
  year={2006},
  volume={444},
  pages={208-212}
}
Bites and stings from venomous creatures can produce pain and inflammation as part of their defensive strategy to ward off predators or competitors. Molecules accounting for lethal effects of venoms have been extensively characterized, but less is known about the mechanisms by which they produce pain. Venoms from spiders, snakes, cone snails or scorpions contain a pharmacopoeia of peptide toxins that block receptor or channel activation as a means of producing shock, paralysis or death. We… Expand
283 Citations
Protein toxins of the Echis coloratus viper venom directly activate TRPV1.
  • 10
Painful toxins acting at TRPV1.
  • B. Cromer, P. McIntyre
  • Biology, Medicine
  • Toxicon : official journal of the International Society on Toxinology
  • 2008
  • 47
Receptor-targeting mechanisms of pain-causing toxins: How ow?
  • 52
A tarantula spider toxin, GsMTx4, reduces mechanical and neuropathic pain
  • 58
  • Highly Influenced
Different types of toxins targeting TRPV1 in pain.
  • 21
A pain-inducing centipede toxin targets the heat activation machinery of nociceptor TRPV1
  • 58
  • PDF
Pain-Causing Venom Peptides: Insights into Sensory Neuron Pharmacology
  • 16
  • Highly Influenced
  • PDF
The Neurotoxic Mode of Action of Venoms from the Spider Family Theraphosidae
  • 14
Animal Toxins Providing Insights into TRPV1 Activation Mechanism
  • 22
  • Highly Influenced
  • PDF
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 34 REFERENCES
The Cloned Capsaicin Receptor Integrates Multiple Pain-Producing Stimuli
  • 2,767
  • PDF
Capsaicin Binds to the Intracellular Domain of the Capsaicin-Activated Ion Channel
  • 283
  • PDF
Molecular Determinants of Vanilloid Sensitivity in TRPV1*
  • 306
  • PDF
Tarantulas: eight-legged pharmacists and combinatorial chemists.
  • P. Escoubas, L. Rash
  • Biology, Medicine
  • Toxicon : official journal of the International Society on Toxinology
  • 2004
  • 189
Conus venoms: a rich source of novel ion channel-targeted peptides.
  • 796
  • PDF
Molecular Surface of Tarantula Toxins Interacting with Voltage Sensors in Kv Channels
  • 91
  • PDF
Solution Structure of Peptide Toxins That Block Mechanosensitive Ion Channels*
  • 90
  • PDF
...
1
2
3
4
...