Spider Silk Fibers Spun from Soluble Recombinant Silk Produced in Mammalian Cells

@article{Lazaris2002SpiderSF,
  title={Spider Silk Fibers Spun from Soluble Recombinant Silk Produced in Mammalian Cells},
  author={A. Lazaris and S. Arcidiacono and Yue-Jin Huang and J. Zhou and F. Duguay and N. Chr{\'e}tien and E. Welsh and J. Soares and C. Karatzas},
  journal={Science},
  year={2002},
  volume={295},
  pages={472 - 476}
}
Spider silks are protein-based “biopolymer” filaments or threads secreted by specialized epithelial cells as concentrated soluble precursors of highly repetitive primary sequences. Spider dragline silk is a flexible, lightweight fiber of extraordinary strength and toughness comparable to that of synthetic high-performance fibers. We sought to “biomimic” the process of spider silk production by expressing in mammalian cells the dragline silk genes (ADF-3/MaSpII and MaSpI) of two spider species… Expand
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