Spicatoside A enhances memory consolidation through the brain-derived neurotrophic factor in mice

@article{Kwon2014SpicatosideAE,
  title={Spicatoside A enhances memory consolidation through the brain-derived neurotrophic factor in mice},
  author={Guyoung Kwon and Hyung Eun Lee and Dong Hwa Lee and Hyun Woo and Jong Hoon Ryu},
  journal={Neuroscience Letters},
  year={2014},
  volume={572},
  pages={58-62}
}
Brain-derived neurotrophic factor (BDNF) plays a pivotal role in memory consolidation. Previously, we found that the increased mature BDNF (mBDNF) levels in the hippocampal region at a specific time window after the acquisition trial are required for memory consolidation. In the present study, we investigated whether spicatoside A enhances memory consolidation, and whether its effects on memory consolidation are related to hippocampal mBDNF levels. Spicatoside A (2.5, 5, 10 or 20mg/kg) enhanced… CONTINUE READING
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