Sphingosylphosphorylcholine stimulates CCL2 production from human umbilical vein endothelial cells.

@article{Lee2011SphingosylphosphorylcholineSC,
  title={Sphingosylphosphorylcholine stimulates CCL2 production from human umbilical vein endothelial cells.},
  author={Ha Young Lee and Sun Young Lee and Sang Doo Kim and Jae Woong Shim and Hak Jung Kim and Young Su Jung and Jae Young Kwon and Suk-hwan Baek and Junho Chung and Hyun Sun Ahn},
  journal={Journal of immunology},
  year={2011},
  volume={186 7},
  pages={
          4347-53
        }
}
Sphingosylphosphorylcholine (SPC) is a component of high-density lipoprotein particles. We investigated the functional role of SPC in HUVECs. SPC stimulation induced production of the CCL2 chemokine in a PTX-sensitive G-protein-dependent manner. SPC treatment caused the activation of NF-κB and AP-1, which are essential for SPC-induced CCL2 production, and induced the activation of three MAPKs, ERK, p38 MAPK, and JNK. Inhibition of p38 MAPK or JNK by specific inhibitors caused a dramatic… CONTINUE READING
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