Sphingosylphosphorylcholine-induced vasoconstriction of pulmonary artery: activation of non-store-operated Ca2+ entry.

@article{Thomas2005SphingosylphosphorylcholineinducedV,
  title={Sphingosylphosphorylcholine-induced vasoconstriction of pulmonary artery: activation of non-store-operated Ca2+ entry.},
  author={Gavin Thomas and Vladimir A. Snetkov and Rupal Patel and Richard M. Leach and Philip I Aaronson and Jeremy P T Ward},
  journal={Cardiovascular research},
  year={2005},
  volume={68 1},
  pages={
          56-64
        }
}
OBJECTIVE Sphingosylphosphorylcholine (SPC) is an important lipid mediator that has been implicated in vascular disease. As it has not been studied in the pulmonary circulation, we examined its mechanisms of action in rat small intrapulmonary arteries (IPA). METHODS IPA were mounted on a myograph for recording tension and intracellular Ca2+ concentration ([Ca2+]i). Ca2+ sensitisation was examined in alpha-toxin permeabilized IPA, and by Western blot analysis of MYPT1 phosphorylation… CONTINUE READING

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