Sphingosylphosphorylcholine down-regulates filaggrin gene transcription through NOX5-based NADPH oxidase and cyclooxygenase-2 in human keratinocytes.

Abstract

Sphingosylphosphorylcholine (SPC) mediates various inflammatory and behavioral responses in atopic dermatitis. Recent studies have shown that dysfunction of the epidermal permeability barrier itself plays a primary role in the etiology of atopic dermatitis. However, the effects of SPC on major proteins essential to the development of the epidermal… (More)
DOI: 10.1016/j.bcp.2010.03.009

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@article{Choi2010SphingosylphosphorylcholineDF, title={Sphingosylphosphorylcholine down-regulates filaggrin gene transcription through NOX5-based NADPH oxidase and cyclooxygenase-2 in human keratinocytes.}, author={Hyun Gon Choi and Shinhyoung Kim and Hyoung-June Kim and Kwang-Mi Kim and Chang Hoon Lee and Jennifer H. Shin and Minsoo Noh}, journal={Biochemical pharmacology}, year={2010}, volume={80 1}, pages={95-103} }