Sphingosine kinase transmits estrogen signaling in human breast cancer cells.

  title={Sphingosine kinase transmits estrogen signaling in human breast cancer cells.},
  author={Olga A Sukocheva and Lijun Wang and Nathaniel O Albanese and Stuart M Pitson and Mathew A. Vadas and Pu Xia},
  journal={Molecular endocrinology},
  volume={17 10},
Current understanding of cytoplasmic signaling pathways that mediate estrogen action in human breast cancer is incomplete. Here we report that treatment with 17beta-estradiol (E2) activates a novel signaling pathway via activation of sphingosine kinase (SphK) in MCF-7 breast cancer cells. We found that E2 has dual actions to stimulate SphK activity, i.e. a rapid and transient activation mediated by putative membrane G protein-coupled estrogen receptors (ER) and a delayed but prolonged… CONTINUE READING
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