Sphingosine kinase interacting protein is an A-kinase anchoring protein specific for type I cAMP-dependent protein kinase.

@article{Kovanich2010SphingosineKI,
  title={Sphingosine kinase interacting protein is an A-kinase anchoring protein specific for type I cAMP-dependent protein kinase.},
  author={Duangnapa Kovanich and Marcel A G van der Heyden and Thin Thin Aye and Toon A B van Veen and Albert J. R. Heck and Arjen Scholten},
  journal={Chembiochem : a European journal of chemical biology},
  year={2010},
  volume={11 7},
  pages={963-71}
}
The compartmentalization of kinases and phosphatases plays an important role in the specificity of second-messenger-mediated signaling events. Localization of the cAMP-dependent protein kinase is mediated by interaction of its regulatory subunit (PKA-R) with the versatile family of A-kinase-anchoring proteins (AKAPs). Most AKAPs bind avidly to PKA-RII, while some have dual specificity for both PKA-RI and PKA-RII; however, no mammalian PKA-RI-specific AKAPs have thus far been assigned. This has… CONTINUE READING