Sphingosine kinase and sphingosine 1-phosphate in the heart: a decade of progress.

@article{Karliner2013SphingosineKA,
  title={Sphingosine kinase and sphingosine 1-phosphate in the heart: a decade of progress.},
  author={Joel S. Karliner},
  journal={Biochimica et biophysica acta},
  year={2013},
  volume={1831 1},
  pages={203-12}
}
Activation of sphingosine kinase/sphingosine 1-phosphate (SK/S1P)-mediated signaling has emerged as a critical cardioprotective pathway in response to acute ischemia/reperfusion injury. S1P is released in both ischemic pre- and post-conditioning. Application of exogenous S1P to cultured cardiac myocytes subjected to hypoxia or treatment of isolated hearts either before ischemia or at the onset of reperfusion exerts prosurvival effects. Synthetic congeners of S1P such as FTY720 mimic these… CONTINUE READING

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Application of exogenous S1P to cultured cardiac myocytes subjected to hypoxia or treatment of isolated hearts either before ischemia or at the onset of reperfusion exerts prosurvival effects .
Gene targeted mice null for the SK1 isoform whose hearts are subjected to ischemia / reperfusion injury exhibit increased infarct size and respond poorly either to ischemic pre- or postconditioning .
Application of exogenous S1P to cultured cardiac myocytes subjected to hypoxia or treatment of isolated hearts either before ischemia or at the onset of reperfusion exerts prosurvival effects .
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