Sphingosine kinase-1 mediates endotoxemia-induced hyperinflammation in aged animals

Abstract

Sepsis is a serious issue in the geriatric population due to its association with high mortality rates in the elderly. The increase in mortality in the elderly correlates with inflammation. We have previously demonstrated that the inflammatory response is exacerbated in a rodent endotoxemia model of sepsis in aged rats compared with young rats. However, the… (More)
DOI: 10.3892/mmr.2013.1562

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