Sphingosine kinase 1-mediated inhibition of Fas death signaling in rheumatoid arthritis B lymphoblastoid cells.

@article{Pi2006SphingosineK1,
  title={Sphingosine kinase 1-mediated inhibition of Fas death signaling in rheumatoid arthritis B lymphoblastoid cells.},
  author={Xiujun Pi and Shi-Yu Tan and Michael Hayes and Liqun Xiao and James A. Shayman and Song Ling and Joseph Holoshitz},
  journal={Arthritis and rheumatism},
  year={2006},
  volume={54 3},
  pages={754-64}
}
OBJECTIVE It is becoming increasingly apparent that B cells play an important role in the pathogenesis of rheumatoid arthritis (RA). Due to the scarcity of B cells in RA, it has been technically difficult to functionally characterize B cell apoptosis in this disease. As a necessary first step to identify candidate aberrations, we investigated Fas-mediated signaling events in immortalized peripheral blood B lymphoblastoid cell lines (LCLs) from patients with RA and controls. METHODS Cell death… CONTINUE READING

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