Sphingosine kinase 1 as an anticancer therapeutic target

  title={Sphingosine kinase 1 as an anticancer therapeutic target},
  author={Ying Gao and Fei Gao and Kan Chen and Mei-li Tian and Dong-li Zhao},
  booktitle={Drug design, development and therapy},
The development of chemotherapeutic resistance is a major challenge in oncology. Elevated sphingosine kinase 1 (SK1) levels is predictive of a poor prognosis, and SK1 overexpression may confer resistance to chemotherapeutics. The SK/sphingosine-1-phosphate (S1P)/sphingosine-1-phosphate receptor (S1PR) signaling pathway has been implicated in the progression of various cancers and in chemotherapeutic drug resistance. Therefore, SK1 may represent an important target for cancer therapy. Targeting… CONTINUE READING
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