Sphingosine kinase 1/sphingosine-1-phosphate regulates the expression of interleukin-17A in activated microglia in cerebral ischemia/reperfusion

@article{Lv2016SphingosineK1,
  title={Sphingosine kinase 1/sphingosine-1-phosphate regulates the expression of interleukin-17A in activated microglia in cerebral ischemia/reperfusion},
  author={Manhua Lv and Dayong Zhang and Dawei Dai and Wei Zhang and Liming Zhang},
  journal={Inflammation Research},
  year={2016},
  volume={65},
  pages={551-562}
}
Microglial activation is one of the causative factors of neuroinflammation in cerebral ischemia/reperfusion (IR). Sphingosine kinase 1 (Sphk1), a key enzyme responsible for phosphorylating sphingosine into sphingosine-1-phosphate (S1P), plays an important role in the regulation of proinflammatory cytokines in activated microglia. Recent research… CONTINUE READING