Sphingosine kinase: Role in regulation of bioactive sphingolipid mediators in inflammation.

@article{Snider2010SphingosineKR,
  title={Sphingosine kinase: Role in regulation of bioactive sphingolipid mediators in inflammation.},
  author={Ashley J. Snider and K Alexa Orr Gandy and Lina M Obeid},
  journal={Biochimie},
  year={2010},
  volume={92 6},
  pages={707-15}
}
Sphingolipids and their synthetic enzymes are emerging as important mediators in inflammatory responses and as regulators of immune cell functions. In particular, sphingosine kinase (SK) and its product sphingosine-1-phosphate (S1P) have been extensively implicated in these processes. SK catalyzes the phosphorylation of sphingosine to S1P and exists as two isoforms, SK1 and SK2. SK1 has been shown to be activated by cytokines including tumor necrosis factor-alpha (TNF-alpha) and interleukin1… CONTINUE READING
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