Sphingosine kinase, sphingosine-1-phosphate, and apoptosis.

@article{Maceyka2002SphingosineKS,
  title={Sphingosine kinase, sphingosine-1-phosphate, and apoptosis.},
  author={Michael W Maceyka and Shawn G. Payne and Sheldon Milstien and Sarah E. Spiegel},
  journal={Biochimica et biophysica acta},
  year={2002},
  volume={1585 2-3},
  pages={
          193-201
        }
}
The sphingolipid metabolites ceramide (Cer), sphingosine (Sph), and sphingosine-1-phosphate (S1P) play an important role in the regulation of cell proliferation, survival, and cell death. Cer and Sph usually inhibit proliferation and promote apoptosis, while the further metabolite S1P stimulates growth and suppresses apoptosis. Because these metabolites are interconvertible, it has been proposed that it is not the absolute amounts of these metabolites but rather their relative levels that… CONTINUE READING

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