Sphingosine increases the permeability of model and cell membranes.

@article{Contreras2006SphingosineIT,
  title={Sphingosine increases the permeability of model and cell membranes.},
  author={F. Xabier Contreras and Jes{\'u}s Sot and Alicia Alonso and F{\'e}lix M Go{\~n}i},
  journal={Biophysical journal},
  year={2006},
  volume={90 11},
  pages={4085-92}
}
Sphingosine, at 5-15 mol % total lipids, remarkably increases the permeability to aqueous solutes of liposomal and erythrocyte ghost membranes. The increased permeability cannot be interpreted in terms of leakage occurring at the early stages of a putative membrane solubilization by sphingosine, nor is it due to a sphingosine-induced generation of nonlamellar structures, or flip-flop lipid movement. Instead, sphingosine stabilizes (rigidifies) gel domains in membranes, raising their melting… CONTINUE READING
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Mitochondrial sphingolipids and the induction of apoptosis

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