Sphingosine forms channels in membranes that differ greatly from those formed by ceramide.

@article{Siskind2005SphingosineFC,
  title={Sphingosine forms channels in membranes that differ greatly from those formed by ceramide.},
  author={Leah J. Siskind and Sharon Fluss and Minh Bui and Marco Colombini},
  journal={Journal of bioenergetics and biomembranes},
  year={2005},
  volume={37 4},
  pages={227-36}
}
Ceramide channels formed in the outer membrane of mitochondria have been proposed to be the pathways by which proapoptotic proteins are released from mitochondria during the early stages of apoptosis. We report that sphingosine also forms channels in membranes, but these differ greatly from the large oligomeric barrel-stave channels formed by ceramide. Sphingosine channels have short open lifetimes and have diameters less than 2 nm, whereas ceramide channels have long open lifetimes, enlarge in… CONTINUE READING