Sphingosine blocks human polymorphonuclear leukocyte phagocytosis through inhibition of mitogen-activated protein kinase activation.

@article{Raeder1999SphingosineBH,
  title={Sphingosine blocks human polymorphonuclear leukocyte phagocytosis through inhibition of mitogen-activated protein kinase activation.},
  author={Evelin Raeder and Pamela J. Mansfield and Vania Hinkovska-Galcheva and Lars Kjeldsen and James A. Shayman and Laurence Boxer},
  journal={Blood},
  year={1999},
  volume={93 2},
  pages={686-93}
}
In the present study, we investigated the mechanism by which sphingosine and its analogues, dihydrosphingosine and phytosphingosine, inhibit polymorphonuclear leukocyte (PMN) phagocytosis of IgG-opsonized erythrocytes (EIgG) and inhibit ERK1 and ERK2 phosphorylation. We used antibodies that recognized the phosphorylated forms of ERK1 (p44) and ERK2 (p42… CONTINUE READING