Sphingosine 1-phosphate transactivates c-Met as well as epidermal growth factor receptor (EGFR) in human gastric cancer cells.

@article{Shida2004Sphingosine1T,
  title={Sphingosine 1-phosphate transactivates c-Met as well as epidermal growth factor receptor (EGFR) in human gastric cancer cells.},
  author={Dai Shida and Joji Kitayama and Hironori Yamaguchi and Hiroharu Yamashita and Ken Mori and Toshiaki Watanabe and Yutaka Yatomi and Hirokazu Nagawa},
  journal={FEBS letters},
  year={2004},
  volume={577 3},
  pages={333-8}
}
Receptor tyrosine kinases (RTKs) are transactivated by the stimulation of G protein-coupled receptors (GPCRs). Sphingosine 1-phosphate (S1P), a ligand of GPCR, is known as a tumor-promoting lipid, but its signaling pathways are not fully understood. We here demonstrated that S1P induces rapid and transient tyrosine phosphorylation of epidermal growth factor receptor (EGFR) and c-Met in gastric cancer cells, both of which have been proposed as prognostic markers of gastric cancers. The pathway… CONTINUE READING
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