Sphingosine 1-phosphate release from platelets during clot formation: close correlation between platelet count and serum sphingosine 1-phosphate concentration

@inproceedings{Ono2013Sphingosine1R,
  title={Sphingosine 1-phosphate release from platelets during clot formation: close correlation between platelet count and serum sphingosine 1-phosphate concentration},
  author={Yoshikazu Ono and Makoto Kurano and Ryunosuke Ohkawa and H. Umezawa'S. Umezawa'M. Yokota and Koji Igarashi and Junken Aoki and Minoru Tozuka and Yutaka Yatomi},
  booktitle={Lipids in Health and Disease},
  year={2013}
}
Sphingosine 1-phosphate (Sph-1-P), abundantly stored in platelets and released extracellularly upon activation, plays important roles as an extracellular mediator by interacting with specific cell surface receptors, especially in the area of vascular biology and immunology/hematology. Although the plasma Sph-1-P level is reportedly determined by red blood cells (RBCs), but not platelets, this may not be true in cases where the platelets have been substantially activated. We measured the Sph-1-P… CONTINUE READING
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