Sphingosine-1-phosphate receptor signalling in the heart.

Abstract

The five known members of the sphingosine-1-phosphate (S1P) receptor family exhibit diverse tissue expression profiles and couple to distinct G-protein-mediated signalling pathways. S1P1, S1P2, and S1P3 receptors are all present in the heart, but the ratio of these subtypes differs for various cardiac cells. The goal of this review is to summarize data… (More)
DOI: 10.1093/cvr/cvp086

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