Sphingosine 1-phosphate receptor modulators: a new class of immunosuppressants.

@article{Yopp2006Sphingosine1R,
  title={Sphingosine 1-phosphate receptor modulators: a new class of immunosuppressants.},
  author={Adam Charles Yopp and Levi G. Ledgerwood and Jordi Ochando and Jonathan S. Bromberg},
  journal={Clinical transplantation},
  year={2006},
  volume={20 6},
  pages={
          788-95
        }
}

• Adam Charles Yopp, Levi G. Ledgerwood, +1 author Jonathan S. Bromberg
• Published 2006 in Clinical transplantation

In this review, we summarize how FTY720 came from the lab bench to the bedside by examining its structural similarities to natural occurring sphingosine analogues, the mechanism of action, and clinical applicability to not only transplantation but also autoimmune, oncological, and neurobiological fields. FTY720, a sphingosine 1-phosphate (S1P) analogue, promotes the survival of human and animal allografts by sequestering T lymphocytes within peripheral lymphoid tissue. The mechanism of… CONTINUE READING

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