Sphingosine 1-phosphate receptor modulators: a new class of immunosuppressants.

  title={Sphingosine 1-phosphate receptor modulators: a new class of immunosuppressants.},
  author={Adam Charles Yopp and Levi G. Ledgerwood and Jordi Ochando and Jonathan S. Bromberg},
  journal={Clinical transplantation},
  volume={20 6},
In this review, we summarize how FTY720 came from the lab bench to the bedside by examining its structural similarities to natural occurring sphingosine analogues, the mechanism of action, and clinical applicability to not only transplantation but also autoimmune, oncological, and neurobiological fields. FTY720, a sphingosine 1-phosphate (S1P) analogue, promotes the survival of human and animal allografts by sequestering T lymphocytes within peripheral lymphoid tissue. The mechanism of… CONTINUE READING
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FTY720 markedly increases alloengraftment but does not eliminate host anti-donor T cells that cause graft rejection on its withdrawal.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation • 2012
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