Sphingosine 1-phosphate receptor agonists attenuate relapsing-remitting experimental autoimmune encephalitis in SJL mice.

@article{Webb2004Sphingosine1R,
  title={Sphingosine 1-phosphate receptor agonists attenuate relapsing-remitting experimental autoimmune encephalitis in SJL mice.},
  author={Michael M. Webb and C J Tham and F. Lin and Karen D Lariosa-Willingham and Naichen Yu and Jeffrey R. Hale and Suzanne Mandala and Jerold Chun and Tadimeti S. Rao},
  journal={Journal of neuroimmunology},
  year={2004},
  volume={153 1-2},
  pages={108-21}
}
FTY720 is a prodrug for FTY-phosphate, an agonist at four of the five known receptors for sphingosine-1-phosphate (S1P). We show that administration of either FTY720 or FTY-P to SJL mice with established relapsing-remitting experimental autoimmune encephalitis (EAE) results in a rapid and sustained improvement in their clinical status, and a reversal of changes in expression of mRNAs encoding some myelin proteins and inflammatory mediators. EAE produced by adoptively transferring lymph node… CONTINUE READING