Sphingosine 1-phosphate receptor 5 mediates the immune quiescence of the human brain endothelial barrier

  title={Sphingosine 1-phosphate receptor 5 mediates the immune quiescence of the human brain endothelial barrier},
  author={Ruben van Doorn and Melissa A Lopes Pinheiro and Gijs Kooij and Kim A M Lakeman and Bert van het Hof and Susanne M. A. van der Pol and Dirk Geerts and Jack van Horssen and P R van der Valk and Elizabeth L van der Kam and Eric Ronken and Arie Reijerkerk and Helga Eveline de Vries},
  booktitle={Journal of Neuroinflammation},
The sphingosine 1-phosphate (S1P) receptor modulator FTY720P (Gilenya®) potently reduces relapse rate and lesion activity in the neuroinflammatory disorder multiple sclerosis. Although most of its efficacy has been shown to be related to immunosuppression through the induction of lymphopenia, it has been suggested that a number of its beneficial effects are related to altered endothelial and blood–brain barrier (BBB) functionality. However, to date it remains unknown whether brain endothelial… CONTINUE READING
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