Sphingosine-1-phosphate receptor-2 function in myeloid cells regulates vascular inflammation and atherosclerosis.

@article{Skoura2011Sphingosine1phosphateRF,
  title={Sphingosine-1-phosphate receptor-2 function in myeloid cells regulates vascular inflammation and atherosclerosis.},
  author={Athanasia Skoura and Jason Michaud and D. B. Im and Shobha Thangada and Yuquan Xiong and Jonathan D Smith and Timothy Hla},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2011},
  volume={31 1},
  pages={81-5}
}
OBJECTIVE Sphingomyelin deposition and metabolism occurs in the atherosclerotic plaque, leading to the formation of sphingosine-1-phosphate (S1P), which activates G protein-coupled receptors to regulate vascular and immune cells. The role of S1P receptors in atherosclerosis has not been examined. METHODS AND RESULTS We tested the hypothesis that S1P receptor-2 (S1PR2) regulates atherosclerosis. Apoe(-/-) S1pr2(-/-) mice showed greatly attenuated atherosclerosis compared with the Apoe… CONTINUE READING
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