Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide.

@article{Giussani2006Sphingosine1phosphatePR,
  title={Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide.},
  author={Paola Giussani and Michael W Maceyka and Herv{\'e} Le Stunff and Aki Mikami and Sandrine L{\'e}pine and Elaine Ying Wang and Samuel Aidan Kelly and Alfred H. Merrill and Sheldon Milstien and Sarah Spiegel},
  journal={Molecular and cellular biology},
  year={2006},
  volume={26 13},
  pages={5055-69}
}
Previous studies demonstrated that sphingosine-1-phosphate (S1P) phosphohydrolase 1 (SPP-1), which is located mainly in the endoplasmic reticulum (ER), regulates sphingolipid metabolism and apoptosis (H. Le Stunff et al., J. Cell Biol. 158:1039-1049, 2002). We show here that the treatment of SPP-1-overexpressing cells with S1P, but not with dihydro-S1P, increased all ceramide species, particularly the long-chain ceramides. This was not due to inhibition of ceramide metabolism to sphingomyelin… CONTINUE READING