Sphingosine 1-phosphate mediates proliferation and survival of mesoangioblasts.

  title={Sphingosine 1-phosphate mediates proliferation and survival of mesoangioblasts.},
  author={Chiara Donati and Francesca Cencetti and Paola Nincheri and Caterina Bernacchioni and Silvia Brunelli and Emilio Clementi and Giulio Cossu and Paola Bruni},
  journal={Stem cells},
  volume={25 7},
Mesoangioblasts are stem cells capable of differentiating in various mesodermal tissues and are presently regarded as suitable candidates for cell therapy of muscle degenerative diseases, as well as myocardial infarction. The enhancement of their proliferation and survival after injection in vivo could greatly improve their ability to repopulate damaged tissues. In this study, we show that the bioactive sphingolipid sphingosine 1-phosphate (S1P) regulates critical functions of mesoangioblast… CONTINUE READING


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