Sphingosine 1-phosphate lyase, a key regulator of sphingosine 1-phosphate signaling and function.

@article{Serra2010Sphingosine1L,
  title={Sphingosine 1-phosphate lyase, a key regulator of sphingosine 1-phosphate signaling and function.},
  author={Montserrat Serra and Julie D Saba},
  journal={Advances in enzyme regulation},
  year={2010},
  volume={50 1},
  pages={349-62}
}
Sphingosine 1-phosphate (S1P) is a polar sphingolipid metabolite that regulates cell migration, differentiation, survival and complex physiological processes (Bartke and Hannun, 2009). S1P functions primarily by activating a subgroup of the endothelial differentiation gene (EDG) family of G-protein coupled cell surface receptors now referred to as S1P1–5 (Lee et al., 1998; Rosen et al., 2009; Van Brocklyn et al., 1998). The biological effects of S1P receptor signaling involve several pathways… CONTINUE READING

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