Sphingosine-1-phosphate is involved in inflammatory reactions in patients with Graves’ orbitopathy

@article{Seo2017Sphingosine1phosphateII,
  title={Sphingosine-1-phosphate is involved in inflammatory reactions in patients with Graves’ orbitopathy},
  author={Yuri Seo and Min Kyung Chae and Sol Ah Han and Eun Jig Lee and Joon H. Lee and Jin Sook Yoon},
  journal={Inflammation Research},
  year={2017},
  volume={66},
  pages={535-545}
}
Graves’ orbitopathy (GO) is initiated by excessive amount of various inflammatory mediators produced by orbital fibroblasts. This study aimed to assess the crucial role of sphingosine-1-phosphate (S1P) in the inflammatory process of GO. Orbital adipose/connective tissue samples were obtained from 10 GO patients and 10 normal control individuals during surgery. Primary orbital fibroblast culture was done. After the expression of S1P receptors and sphingosine kinase (SphK) was assessed with the… CONTINUE READING