Sphingosine 1-phosphate is a novel inhibitor of T-cell proliferation.

@article{Jin2003Sphingosine1I,
  title={Sphingosine 1-phosphate is a novel inhibitor of T-cell proliferation.},
  author={Yixin Jin and Eirunn Knudsen and Ling Wang and Yenan T Bryceson and Bassam B. Damaj and S Gessani and Azzam A Maghazachi},
  journal={Blood},
  year={2003},
  volume={101 12},
  pages={
          4909-15
        }
}
Sphingosine 1-phosphate (S1P) is a pleiotropic lysosphingophospholipid stored and secreted by platelets. Using reverse transcription-polymerase chain reaction and flow cytometric analyses, we determined the expression of S1P receptors (S1P1, S1P3, S1P4, and S1P5) in peripheral blood T cells. T cells were induced to proliferate in the presence of phorbol 12-myristate 13-acetate (PMA) plus ionomycin, anti-CD3 plus anti-CD28, and allogeneic immature or mature dendritic cells. This activity was… CONTINUE READING

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