Sphingosine-1-phosphate inhibits interleukin-1β-induced inflammation in human articular chondrocytes.

@article{Moon2012Sphingosine1phosphateII,
  title={Sphingosine-1-phosphate inhibits interleukin-1β-induced inflammation in human articular chondrocytes.},
  author={Myung-Hee Moon and J Y Jeong and You-Jin Lee and J G Seol and Sang-Youel Park},
  journal={International journal of molecular medicine},
  year={2012},
  volume={30 6},
  pages={1451-8}
}
Sphingosine-1-phosphate (S1P) is a pluripotent lipid mediator that transmits signals through a family of G-protein-coupled receptors (GPCRs) to control diverse biological processes including inflammation and wound-healing. In this study, a novel biological activity of S1P in articular chondrocytes was identified. Human primary chondrocytes were cultured in a monolayer. Reverse transcription-polymerase chain reaction (RT-PCR) and western blotting were performed to detect genes and proteins… CONTINUE READING
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