Sphingosine-1-phosphate induces proliferation and morphological changes of neural progenitor cells.

@article{Harada2004Sphingosine1phosphateIP,
  title={Sphingosine-1-phosphate induces proliferation and morphological changes of neural progenitor cells.},
  author={Jun Harada and Melissa A Foley and Michael A. Moskowitz and Christian Waeber},
  journal={Journal of neurochemistry},
  year={2004},
  volume={88 4},
  pages={1026-39}
}
Sphingosine-1-phosphate (S1P) is a lipid mediator that exerts multiple cellular functions through activation of G-protein-coupled receptors. Although the role of S1P on angiogenesis is well established, its role in neurogenesis is unknown. We examined the effects of S1P on G-protein activation in brain sections of rat embryo and on neural progenitor cells in culture. Intense S1P-stimulated [35S]GTPgammaS labeling was observed as early as E15 in the neuroepithelium and differentiating fields… CONTINUE READING
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