Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.

Abstract

Activated macrophages acquire a proinflammatory (classic) or antiinflammatory (alternative) phenotype that influences atherosclerosis. The present study investigated whether sphingosine-1-phosphate (S1P), with its known antiinflammatory effects, could regulate the inflammatory phenotype of lipopolysaccharide (LPS)-stimulated mouse macrophages. Activation of… (More)
DOI: 10.1161/CIRCRESAHA.107.170779

Topics

6 Figures and Tables