Sphingosine-1-phosphate evokes unique segment-specific vasoconstriction of the renal microvasculature.

@article{Guan2014Sphingosine1phosphateEU,
  title={Sphingosine-1-phosphate evokes unique segment-specific vasoconstriction of the renal microvasculature.},
  author={Zhengrong Guan and Sean T. Singletary and Anthony K. Cook and Janet L. Hobbs and Jennifer S Pollock and Edward W. Inscho},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2014},
  volume={25 8},
  pages={
          1774-85
        }
}
Sphingosine-1-phosphate (S1P), a bioactive sphingolipid metabolite, has been implicated in regulating vascular tone and participating in chronic and acute kidney injury. However, little is known about the role of S1P in the renal microcirculation. Here, we directly assessed the vasoresponsiveness of preglomerular and postglomerular microvascular segments to exogenous S1P using the in vitro blood-perfused juxtamedullary nephron preparation. Superfusion of S1P (0.001-10 μM) evoked concentration… CONTINUE READING

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