Sphingosine 1-phosphate enhances the excitability of rat sensory neurons through activation of sphingosine 1-phosphate receptors 1 and/or 3

@article{Li2015Sphingosine1E,
  title={Sphingosine 1-phosphate enhances the excitability of rat sensory neurons through activation of sphingosine 1-phosphate receptors 1 and/or 3},
  author={Chao Li and Jun-nan Li and Joanne S Kays and Miguel Guerrero and Grant D. Nicol},
  journal={Journal of Neuroinflammation},
  year={2015},
  volume={12}
}
BackgroundSphingosine-1-phosphate (S1P) is a bioactive sphingolipid that acts through a family of five G-protein-coupled receptors (S1PR1–5) and plays a key role in regulating the inflammatory response. Our previous studies demonstrated that rat sensory neurons express the mRNAs for all five S1PRs and that S1P increases neuronal excitability primarily, but not exclusively, through S1PR1. This raises the question as to which other S1PRs mediate the enhanced excitability.MethodsIsolated sensory… Expand
Sphingosine-1-Phosphate and the S1P3 Receptor Initiate Neuronal Retraction via RhoA/ROCK Associated with CRMP2 Phosphorylation
TLDR
The improved sensory recovery after crush injury further supported the relevance of a critical role for S1P and receptors in fine-tuning axonal outgrowth in peripheral neurons. Expand
Differential contribution of sensory transient receptor potential channels in response to the bioactive lipid sphingosine-1-phosphate
TLDR
It is revealed that S1P induces both pain and itch in vivo and that these responses are partially dependent upon the TRPV1, but not TRPA1 channels. Expand
Activation of sphingosine-1-phosphate receptor subtype 1 in the central nervous system contributes to morphine-induced hyperalgesia and antinociceptive tolerance in rodents.
TLDR
The results identify S1 PR1 as a critical path for S1P signaling in response to sustained morphine and reveal downstream neuroinflammatory pathways impacted by S1PR1 activation. Expand
Sphingosine 1-phosphate receptor subtype 3 (S1P3) contributes to brain injury after transient focal cerebral ischemia via modulating microglial activation and their M1 polarization
TLDR
This study identified S1P3 as a pathogenic mediator in an ischemic brain along with underlying mechanisms, involving its modulation of microglial activation and M1 polarization, further suggesting that S 1P3 can be a therapeutic target for cerebral ischemia. Expand
Lessons from S1P receptor targeting in multiple sclerosis.
Sphingosine 1-phosphate (S1P) is a potent bioactive sphingolipid binding to specific G protein-coupled receptors expressed in several organs. The relevance of S1P-S1P receptor axis in theExpand
The Sphingosine 1-Phosphate Signaling Pathway in Epilepsy: A Possible Role for the Immunomodulator Drug Fingolimod in Epilepsy Treatment.
TLDR
The objective of this manuscript is to review the biological role of S1P and its receptors, focusing on their expression, effects and possible involvement in epilepsy, and to conclude that fingolimod, being already commercially available, might be easily tested for its possible therapeutic effectiveness in epileptic patients. Expand
Crosstalk between sphingolipids and vitamin D3: potential role in the nervous system
TLDR
The potential crosstalk between sphingolipids and 1,25(OH)2D3 in neural cells is focused on and it is still not known whether they can act synergistically. Expand
The signaling lipid sphingosine 1-phosphate regulates mechanical pain
TLDR
This work shows that the bioactive lipid sphingosine 1-phosphate (S1P) and S1P Receptor 3 (S 1PR3) are critical regulators of acute mechanonociception and defines a new role for S1PR3 in regulating neuronal excitability and establishes the importance of S 1P/S1 PR3 signaling in the setting of mechanical pain thresholds. Expand
The signaling lipid sphingosine 1-phosphate regulates mechanical pain
TLDR
This work shows that the bioactive lipid sphingosine 1-phosphate (S1P) and S1P Receptor 3 (S 1PR3) are critical regulators of acute mechanonociception and defines a new role for S1PR3 in regulating neuronal excitability and establishes the importance of S 1P/S1 PR3 signaling in the setting of mechanical pain thresholds. Expand
Mechanisms of sphingosine 1-phosphate receptor signalling in cancer.
TLDR
There is strong evidence implicating the involvement of S1P receptors (S1PRs) in cancer progression and the recent evidence to suggest cross-talk between the S1 PRs and other cellular signalling pathways in cancer. Expand
...
1
2
3
4
...

References

SHOWING 1-10 OF 76 REFERENCES
The sphingosine 1-phosphate receptor, S1PR₁, plays a prominent but not exclusive role in enhancing the excitability of sensory neurons.
TLDR
It is reported that exposure to the selective S1PR(1) agonist, SEW2871, produced a significant increase in excitability of some, but not all, sensory neurons, and this results indicate that S1 PR( 1) plays a prominent, although not exclusive, role in mediating the enhancement of excitability produced by S1P. Expand
Sphingosine-1-phosphate via activation of a G-protein-coupled receptor(s) enhances the excitability of rat sensory neurons.
TLDR
Findings demonstrate that S1P can regulate the excitability of small diameter sensory neurons by acting as an external paracrine-type ligand through activation of G-protein-coupled receptors and thus may contribute to the hypersensitivity during inflammation. Expand
Knockdown of the sphingosine-1-phosphate receptor S1PR1reduces pain behaviors induced by local inflammation of the rat sensory ganglion
TLDR
It is found that in vivo perfusion of the normal L5 DRG with S1P increased mechanical sensitivity, and the results indicate that the S1PR1 receptors in sensory ganglia cells may play an important role in regulating behavioral sensitivity during inflammation. Expand
Sphingosine 1-phosphate receptor 2 antagonist JTE-013 increases the excitability of sensory neurons independently of the receptor.
TLDR
Exposure to JTE-013 alone produced a significant increase in excitability in a time- and concentration-dependent manner in 70-80% of recorded neurons, indicating that J TE-013 augments neuronal excitability independently of S1 PR(2) by unknown mechanisms that may involve activation of other G protein-coupled receptors such as S1PR(1). Expand
Expression of sphingosine 1-phosphate receptors in the rat dorsal root ganglia and defined single isolated sensory neurons.
TLDR
The results obtained from the single defined neurons are consistent with previous findings wherein S1PR(1) plays a prominent but not exclusive role in the enhancement of neuronal excitability. Expand
Sphingosine-1-phosphate receptors as emerging targets for treatment of pain.
TLDR
Evidence suggests that drugs targeting the S1P system could be developed as novel analgesics, either as monotherapy or potential adjuncts to established analgesics. Expand
Role for peroxynitrite in sphingosine-1-phosphate-induced hyperalgesia in rats
TLDR
Sphingosine‐1‐phosphate‐induced hyperalgesia is mediated by S1P1 receptor activation and mitigated by inhibition or decomposition of peroxynitrite, providing a target pathway for novel pain management strategies. Expand
Sphingosine-1-Phosphate-Induced Nociceptor Excitation and Ongoing Pain Behavior in Mice and Humans Is Largely Mediated by S1P3 Receptor
TLDR
It is found that intradermal injection of S1P induced significant licking and flinching behavior in wild-type mice and a dose-dependent flare reaction in human skin as a sign of acute activation of nociceptive nerve terminals and point to these receptors as valuable therapeutic targets for post-traumatic pain. Expand
Sphingosine 1-phosphate signalling via the endothelial differentiation gene family of G-protein-coupled receptors.
TLDR
The major focus is on the ability of S1P to bind to a novel family of G-protein-coupled receptors to elicit signal transduction and to act as a pleiotropic bioactive lipid with an important role in cellular regulation. Expand
Nerve growth factor enhances the excitability of rat sensory neurons through activation of the atypical protein kinase C isoform, PKMζ.
TLDR
It is demonstrated that NGF leads to the activation of PKMζ that ultimately enhances the capacity of small-diameter capsaicin-sensitive sensory neurons to fire APs through a PI3K-dependent signaling cascade. Expand
...
1
2
3
4
5
...