Sphingosine 1-phosphate differentially regulates proliferation of C2C12 reserve cells and myoblasts

@article{Rapizzi2008Sphingosine1D,
  title={Sphingosine 1-phosphate differentially regulates proliferation of C2C12 reserve cells and myoblasts},
  author={Elena Rapizzi and Chiara Donati and Francesca Cencetti and Paola Nincheri and Paola Bruni},
  journal={Molecular and Cellular Biochemistry},
  year={2008},
  volume={314},
  pages={193-199}
}
The effect of sphingosine 1-phosphate (S1P) on the proliferative response to low serum was examined in two closely related cell populations, such as C2C12 reserve cells and myoblasts. S1P reduced DNA synthesis promoted by serum in myoblasts, whereas it enhanced the mitogenic response to serum in reserve cells. By employing selective S1P receptor agonist and antagonists, the co-mitogenic action of S1P in reserve cells was shown to depend mainly on S1P1. Real time PCR analysis revealed distinct… CONTINUE READING

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