Sphingosine 1-phosphate counteracts insulin signaling in pancreatic β-cells via the sphingosine 1-phosphate receptor subtype 2.

@article{Japtok2015Sphingosine1C,
  title={Sphingosine 1-phosphate counteracts insulin signaling in pancreatic β-cells via the sphingosine 1-phosphate receptor subtype 2.},
  author={Lukasz Japtok and Elisabeth I. Schmitz and Susann Fayyaz and Stephanie Kr{\"a}mer and Leigh J Hsu and Burkhard Kleuser},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2015},
  volume={29 8},
  pages={3357-69}
}
Glucolipotoxic stress has been identified as a key player in the progression of pancreatic β-cell dysfunction contributing to insulin resistance and the development of type 2 diabetes mellitus (T2D). It has been suggested that bioactive lipid intermediates, formed under lipotoxic conditions, are involved in these processes. Here, we show that sphingosine 1-phosphate (S1P) levels are not only increased in palmitate-stimulated pancreatic β-cells but also regulate β-cell homeostasis in a divergent… CONTINUE READING
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