Sphingosine-1-phosphate and sphingosylphosphorylcholine: two of a kind?

  title={Sphingosine-1-phosphate and sphingosylphosphorylcholine: two of a kind?},
  author={Astrid E. Alewijnse and Martin C Michel},
  journal={British journal of pharmacology},
  volume={147 4},
Sphingosine-1-phosphate and sphingosylphosphorylcholine are structurally related signalling molecules. Although they share some biological effects, it is debated whether this involves the same receptors. In this issue, Mathieson and Nixon report that these two lipids activate the same transcription factor but do so via distinct signalling pathways. Against this background, we discuss some of the potential pitfalls in studies comparing the effects of the two sphingolipids.