Sphingosine-1-phosphate and lysophosphatidic acid trigger invasion of primitive hematopoietic cells into stromal cell layers.

@article{Yanai2000Sphingosine1phosphateAL,
  title={Sphingosine-1-phosphate and lysophosphatidic acid trigger invasion of primitive hematopoietic cells into stromal cell layers.},
  author={Nobuaki Yanai and Naohiko Matsui and Tadashi Furusawa and Tadashi Okubo and Masuo Obinata},
  journal={Blood},
  year={2000},
  volume={96 1},
  pages={
          139-44
        }
}
A new primitive hematopoietic cell line (THS119), exhibiting Lin(-)/Sca-1(+)/c-Kit(+) a surface phenotype, grew and survived underneath stromal cells (TBR59). The ability of the THS119 cells to invade these stromal cell layers was dependent on the inclusion of serum in the culture medium. This was apparently due to a requirement for lipids contained in serum. Their invasion of the stromal cell layers in serum-free cultures could be triggered by addition of sphingosine-1-phosphate (S1P) or… CONTINUE READING

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