Sphingosine 1-phosphate activates Weibel-Palade body exocytosis.

  title={Sphingosine 1-phosphate activates Weibel-Palade body exocytosis.},
  author={Kenji Matsushita and Craig N. Morrell and Charles J Lowenstein},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={101 31},
Sphingosine 1-phosphate (S1P) not only regulates angiogenesis, vascular permeability and vascular tone, but it also promotes vascular inflammation. However, the molecular basis for the proinflammatory effects of S1P is not understood. We now show that S1P activates endothelial cell exocytosis of Weibel-Palade bodies, releasing vasoactive substances capable of causing vascular thrombosis and inflammation. S1P triggers endothelial exocytosis in part through phospholipase C-gamma signal… CONTINUE READING