Sphingosine-1-phosphate: signaling inside and out.

  title={Sphingosine-1-phosphate: signaling inside and out.},
  author={Sarah Spiegel and Sheldon Milstien},
  journal={FEBS letters},
  volume={476 1-2},
Ample evidence indicates that sphingosine-1-phosphate (SPP) can serve as an intracellular second messenger regulating calcium mobilization, and cell growth and survival. Moreover, the dynamic balance between levels of the sphingolipid metabolites, ceramide and SPP, and consequent regulation of opposing signaling pathways, is an important factor that determines whether a cell survives or dies. SPP has recently also been shown to be the ligand for the EDG-1 family of G-protein-coupled receptors… CONTINUE READING

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