Sphingosine-1-phosphate: an enigmatic signalling lipid

@article{Spiegel2003Sphingosine1phosphateAE,
  title={Sphingosine-1-phosphate: an enigmatic signalling lipid},
  author={Sarah Spiegel and Sheldon Milstien},
  journal={Nature Reviews Molecular Cell Biology},
  year={2003},
  volume={4},
  pages={397-407}
}
The evolutionarily conserved actions of the sphingolipid metabolite, sphingosine-1-phosphate (S1P), in yeast, plants and mammals have shown that it has important functions. In higher eukaryotes, S1P is the ligand for a family of five G-protein-coupled receptors. These S1P receptors are differentially expressed, coupled to various G proteins, and regulate angiogenesis, vascular maturation, cardiac development and immunity, and are important for directed cell movement. 
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